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Literature summary for 3.1.21.1 extracted from

  • Ershova, E.; Sergeeva, V.; Klimenko, M.; Avetisova, K.; Klimenko, P.; Kostyuk, E.; Veiko, N.; Veiko, R.; Izevskaya, V.; Kutsev, S.; Kostyuk, S.
    Circulating cell-free DNA concentration and DNase I activity of peripheral blood plasma change in case of pregnancy with intrauterine growth restriction compared to normal pregnancy (2017), Biomed. Rep., 7, 319-324 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics cell-free DNA circulating in blood cannot be a reliable marker of increased cell death during pregnancy. Thus, assessment of the level of cell death during pregnancy should be done by simultaneous analysis of cell-free DNA level and DNase I activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P24855
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma blood plasma of 40 non-pregnant women, 40 healthy pregnant women (over 37 weeks) and 40 pregnant women with a diagnosis of intrauterine growth restriction Homo sapiens
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Synonyms

Synonyms Comment Organism
DNase I
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens significant increase of DNase I activity in cases of intrauterine growth restriction. Increase in DNase I activity over a certain threshold indicates presence of pathological processes in the organism up