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Literature summary for 3.1.21.1 extracted from

  • Wahlberg, K.; Jiang, J.; Rooks, H.; Jawaid, K.; Matsuda, F.; Yamaguchi, M.; Lathrop, M.; Thein, S.L.; Best, S.
    The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells (2009), Blood, 114, 1254-1262.
    View publication on PubMed
Search for more literature for 3.1.21.1

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
erythroid cell
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 Homo sapiens
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JURKAT cell
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 Homo sapiens
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K-562 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HMIP-2 + H2O identifies three tissue-specific DNase I hypersensitive sites in the core intergenic interval Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
DNase I
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 Homo sapiens

General Information

General Information Comment Organism
physiological function in uninduced K-562 cells, several sites within HMIP-2 show sensitivity to DNase I above background levels. When cells are induced to differentiate, the region shows a general increase in DNase I sensitivity: 3 sites refer to here as HBS1L-MYB HS1, HS2, and HS3, in particular, show a marked increase in sensitivity compared with background levels. DNase I sensitivity also increases for betaHS2 and betaHS3 controls. HBS1L-MYB HS1, HS2, and HS3 also show stronger sensitivity to DNase I than the betaHS3 control, thereby reaching a threshold level for hypersensitivity. No difference in DNase I sensitivity for NEFM in uninduced and induced K-562 cells. BetaHS2 is not sensitive to DNase I in Jurkat cells. Jurkat cells show similar background levels and generally, a similar DNase I sensitivity profile to induced K562 cells, but with much less sensitivity at HBS1L-MYB HS1, HS2, and HS3. The strongest sensitivity to DNase I in Jurkat cells coincides with the putative promoter region of the alternative HBS1L exon (exon 1a), which shows a low degree of sensitivity in K-562 cells (both uninduced and induced) Homo sapiens