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Literature summary for 3.1.21.1 extracted from

  • Coulon, S.; Gaillard, P.h.L.; Chahwan, C.; McDonald, W.H.; Yates, J.R.3rd.; Russell, P.
    Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast (2004), Mol. Biol. Cell, 15, 71-80.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.21.1

Activating Compound

Activating Compound Comment Organism Structure
Slx4 the Slx4 protein is essential for efficient processing of DNA substrates Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
R334A/E74A inactive Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 5 mM Schizosaccharomyces pombe

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ highest activity at 2.5 mM Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
double-stranded DNA + H2O different structure-specific DNA substrates representing stem loop structures with different loop length were used as substrate. Slx1 cuts these substrates at th 3' side of double-strand/single-strand junctions Schizosaccharomyces pombe 5'-phosphooligonucleotides + ?
-
 ?

Synonyms

Synonyms Comment Organism
Slx1
-
 Schizosaccharomyces pombe