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Literature summary for 3.1.21.1 extracted from

  • Peitsch, M.C.; Polzar, B.; Stephan, H.; Crompton, T.; MacDonald, H.R.; Mannherz, H.G.; Tschopp, J.
    Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death) (1993), EMBO J., 12, 371-377.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.21.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
 Rattus sp.
G-actin inhibition with actin-gelsolin segment I complex Rattus sp.
Zn2+ inhibition at millimolar concentrations Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus sp. 5737
-
nucleus
-
 Rattus sp. 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus sp.
Mg2+
-
 Rattus sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 SDS-PAGE Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
double-stranded DNA + H2O Rattus sp. involved in DNA degradation during apoptosis 5'-phosphooligonucleotides + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymph node
-
 Rattus sp.
-
thymocyte
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
circular plasmid DNA + H2O
-
 Rattus sp. 5'-phosphooligonucleotides + ?
-
 ?
double-stranded DNA + H2O involved in DNA degradation during apoptosis Rattus sp. 5'-phosphooligonucleotides + ?
-
 ?