Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-2-methylpropanoyl-CoA + H2O | Homo sapiens | key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo | CoA + 3-hydroxy-2-methylpropanoate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma cell | 46% reduced activity compared to healthy cells | Homo sapiens | - |
liver | 36% reduced activity in livers with chronic hepatitis and cirrhosis compared to healthy livers | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-2-methylpropanoyl-CoA + H2O | - |
Homo sapiens | CoA + 3-hydroxy-2-methylpropanoate | - |
ir | |
3-hydroxy-2-methylpropanoyl-CoA + H2O | key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo | Homo sapiens | CoA + 3-hydroxy-2-methylpropanoate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
beta-hydroxyisobutyryl-coenzyme A hydrolase | - |
Homo sapiens |
HIB-CoA hydrolase | - |
Homo sapiens |