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Literature summary for 3.1.2.27 extracted from
- Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts (2000), J. Lipid Res., 41, 1154-1162.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | high activity | Homo sapiens | 5829 | - |
| microsome | - |
Homo sapiens | - |
- |
| mitochondrion | especially in the light mitochondrial fraction | Homo sapiens | 5739 | - |
| additional information | subcellular distribution, overview | Homo sapiens | - |
- |
| nucleus | - |
Homo sapiens | 5634 | - |
| peroxisome | highest enzyme activity | Homo sapiens | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chenodeoxycholoyl-CoA + H2O | Homo sapiens | - |
chenodeoxycholate + CoA | - |
? |  |
| choloyl-CoA + H2O | Homo sapiens | - |
cholate + CoA | - |
? | |
| additional information | Homo sapiens | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially, subcellular fractionation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0014 | 0.0031 | subcellular fractions, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chenodeoxycholoyl-CoA + H2O | - |
Homo sapiens | chenodeoxycholate + CoA | - |
? | |
| choloyl-CoA + H2O | - |
Homo sapiens | cholate + CoA | - |
? | |
| additional information | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bile acid-CoA thioesterase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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