Literature summary for 3.1.2.22 extracted from

Liu, Y.; Zhao, W.; Gu, G.; Lu, L.; Feng, J.; Guo, Q.; Ding, Z.
Palmitoyl-protein thioesterase 1 (PPT1): an obesity-induced rat testicular marker of reduced fertility (2014), Mol. Reprod. Dev., 81, 55-65.

Search for more literature for 3.1.2.22

Application

Application	Comment	Organism
nutrition	the litter sizes for females mated to obese males are significantly lower as compared to females mated with normal-diet-fed controls. Their serum high-density lipoprotein, low-density lipoprotein, cholesterol, and estradiol levels increase in obese males, but testosterone and follicle-stimulating hormone levels decrease. Testicular morphology disruptions include Sertoli-cell atrophy, disrupted tight junctions, and mitochondrial degeneration in spermatogenic cells. In rats fed a high-fat diet, palmitoyl-protein thioesterase PPT1 is upregulated. In a Sertoli-cell line cultured in a high-fat supplemented medium, PPT1 abundance Is accompanied by increases in the endocytic vesicle-associated protein, clathrin, and decreases in the tight junctional proteins, ZO-1 and occludin	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P45479	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Sertoli cell	-	Rattus norvegicus	-
testis	-	Rattus norvegicus	-

Expression

Organism	Comment	Expression
Rattus norvegicus	in rats fed a high-fat diet, palmitoyl-protein thioesterase PPT1 is upregulated. In a Sertoli-cell line cultured in a high-fat supplemented medium, PPT1 abundance Is accompanied by increases in the endocytic vesicle-associated protein, clathrin, and decreases in the tight junctional proteins, ZO-1 and occludin	up

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Release 2023.1 (January 2023)