Literature summary for 3.1.2.22 extracted from

Aby, E.; Gumps, K.; Roth, A.; Sigmon, S.; Jenkins, S.E.; Kim, J.J.; Kramer, N.J.; Parfitt, K.D.; Korey, C.A.
Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae (2014), Fly, 7, 267-279.

Search for more literature for 3.1.2.22

Cloned(Commentary)

Cloned (Comment)	Organism
-	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
A179T	loss-of-function mutant, shows an increased frequency of mini excitatory junctional potentials, defects in vesicle cycling during and following repetitive stimulation, and a decreased rate of fluorescent endocytic tracer FM1-43 endocytosis	Drosophila melanogaster
S77F	loss-of-function mutant, shows an increased frequency of mini excitatory junctional potentials, defects in vesicle cycling during and following repetitive stimulation, and a decreased rate of fluorescent endocytic tracer FM1-43 endocytosis	Drosophila melanogaster

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9W3C7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
larva	-	Drosophila melanogaster	-

General Information

General Information	Comment	Organism
physiological function	mutations in palmitoyl-protein thioesterase Ppt1 genetically interact with temperature sensitive mutations in the Drosophila dynamin gene shibire, accelerating the paralytic behavior of shibire mutants at 27°C. Ppt1-deficient larvae show an increase in miniature excitatory junctional potentials and a significant depression of evoked excitatory junctional potentials in response to repetitive stimulation. In Ppt1-mutant larvae, there is a significant decrease in fluorescent endocytic tracer FM1-43 uptake at the mutant neuromuscular junction. Ppt1-deficient and Ppt1 point mutant larvae display defects in locomotion that are consistent with alterations in synaptic function	Drosophila melanogaster

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Release 2023.1 (January 2023)