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Literature summary for 3.1.2.22 extracted from

  • Lehtovirta, M.; Kyttala, A.; Eskelinen, E.L.; Hess, M.; Heinonen, O.; Jalanko, A.
    Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL) (2001), Hum. Mol. Genet., 10, 69-75.
    View publication on PubMed
Search for more literature for 3.1.2.22

Cloned(Commentary)

Cloned (Comment) Organism
expression as glutathione S-transferase fusion protein in BHK and CHO cells, localization of the recombinant enzyme out side the lysosomes and endosomes Mus musculus
expression of the enzyme in Caco-2 cells, orientation to the basolateral side, also after endocytosis of the recombinant enzyme into Caco-2 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome Homo sapiens 5764
-
additional information not in lysosomes of mouse brain or neurons Mus musculus
-
-
synaptic vesicle
-
 Mus musculus 8021
-
synaptosome
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 x * 37000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL ?
-
 ?
additional information Mus musculus the enzyme has a role outside the lysosome in the brain and might be associated with synaptic functioning ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Mus musculus
a
palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
Caco-2 cell exclusively localized to the basolateral side of the polarized cells Homo sapiens
-
epithelium
-
 Homo sapiens
-
neuron
-
 Mus musculus
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL Homo sapiens ?
-
 ?
additional information the enzyme has a role outside the lysosome in the brain and might be associated with synaptic functioning Mus musculus ?
-
 ?
palmitoyl-[protein] + H2O
-
 Mus musculus palmitate + protein
-
 ?
palmitoyl-[protein] + H2O
-
 Homo sapiens palmitate + protein
-
 ?

Subunits

Subunits Comment Organism
? x * 37000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
palmitoyl protein thioesterase
-
 Mus musculus
palmitoyl protein thioesterase
-
 Homo sapiens
PPT
-
 Mus musculus
PPT
-
 Homo sapiens