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Literature summary for 3.1.2.20 extracted from

  • Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.
    Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase (1999), J. Biochem., 126, 1013-1019.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis, chromosome mapping 1p36.2, expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0064
-
hexadecanoyl-CoA pH 7.4, 30°C Homo sapiens
0.0076
-
dodecanoyl-CoA pH 7.4, 30°C Homo sapiens
0.0088
-
oleoyl-CoA pH 7.4, 30°C Homo sapiens
0.0092
-
Arachidonoyl-CoA pH 7.4, 30°C Homo sapiens
0.014
-
octanoyl-CoA pH 7.4, 30°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
n * 43000, enzyme is a dimer or a trimer of MW 100 kDa, SDS-PAGE Homo sapiens
100000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00154 human brain long-chain acyl-CoA hydrolase hBACH
-

Purification (Commentary)

Purification (Comment) Organism
from brain Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
198
-
purified native enzyme, substrate palmitoyl-CoA Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + H2O acyl-CoA of chain length C8-C18 Homo sapiens CoA + a carboxylate
-
?
acyl-CoA + H2O long-chain fatty-acyl-CoA Homo sapiens CoA + a carboxylate
-
?
arachidonoyl-CoA + H2O
-
Homo sapiens CoA + arachidonate
-
?
dodecanoyl-CoA + H2O
-
Homo sapiens CoA + dodecanoate
-
?
hexadecanoyl-CoA + H2O best substrate Homo sapiens CoA + hexadecanoate
-
?
hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Homo sapiens CoA + hexadecanoate
-
?
octanoyl-CoA + H2O
-
Homo sapiens CoA + octanoate
-
?
oleoyl-CoA + H2O
-
Homo sapiens CoA + oleate
-
?

Subunits

Subunits Comment Organism
oligomer n * 43000, enzyme is a dimer or a trimer of MW 100 kDa, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens