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Literature summary for 3.1.2.1 extracted from

  • Robinson, J.B.; Mahan, D.E.; Koeppe, R.E.
    Studies on rat brain acyl-coenzyme A hydrolase (short chain) (1976), Biochem. Biophys. Res. Commun., 71, 959-965.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetate hydrolase increased 3fold by 100-250 mM acetate Rattus norvegicus
DL-beta-hydroxy-butyrate hydrolase increases 50-70% by 100 mM DL-beta-hydroxy-butyrate Rattus norvegicus
fluoroacetate hydrolase increases 50-70% by 100 mM fluoroacetate Rattus norvegicus
propionate hydrolase increases 50-70% by 250 mM propionate Rattus norvegicus

General Stability

General Stability Organism
sulfhydryl compounds, glycerol and high ionic strength in the range of 0.2-0.4 mM enhances stability during purification Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ADP 1-10 mM inhibits Rattus norvegicus
ATP 0.5 mM nucleoside phosphate inhibits 49% in Trypanosoma brucei brucei 427; 1-10 mM inhibits the enzyme Rattus norvegicus
CoA 0.1 mM causes over 50% inhibition Rattus norvegicus
DL-lipoic acid
-
Rattus norvegicus
phosphate 50% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
155000
-
gel filtration Rattus norvegicus
160000
-
sedimentation velocity in a sucrose density gradient Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
1375fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
cerebellum
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-
pons
-
Rattus norvegicus
-
telencephalon
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
4 months, 4°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA
-
Rattus norvegicus acetoacetate + CoA
-
?
acetyl-CoA + H2O
-
Rattus norvegicus CoA + acetate
-
?
acetyl-CoA + H2O
-
Rattus norvegicus ?
-
?
butyryl-CoA + H2O
-
Rattus norvegicus butanoate + CoA
-
?
malonyl-CoA
-
Rattus norvegicus malonate + CoA
-
?
octanoyl-CoA
-
Rattus norvegicus octanoate + CoA
-
?
propionyl-CoA + H2O
-
Rattus norvegicus CoA + propionate
-
?
succinyl-CoA
-
Rattus norvegicus succinate + CoA
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
-
Rattus norvegicus