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Literature summary for 3.1.15.1 extracted from

  • Honcharenko, D.; Barman, J.; Varghese, O.P.; Chattopadhyaya, J.
    Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2-alkoxy modified oligonucleotides (2007), Biochemistry, 46, 5635-5646.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Crotalus adamanteus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-(dCTTCA-(2'-azetidine)T-TTTTTCTTC)-3' + H2O azetidine-T modified antisense oligonucleotide 11 degradation goes faster with respect to the antisense oligonucleotides 2-5 Crotalus adamanteus ?
-
?
5'-(dCTTCA-(2'-N-4'-C-ethylene-bridged)T-TTTTTCTTC)-3' + H2O 2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 5 still remains undegraded to certain extent Crotalus adamanteus ?
-
?
5'-(dCTTCA-(2'-O-(2-methoxy)ethyl)T-TTTTTCTTC)-3' + H2O for 2'-O-methyl-T modified antisense oligonucleotide 7 degradation goes faster with respect to the antisense oligonucleotides 2-5 Crotalus adamanteus ?
-
?
5'-(dCTTCA-(2'-O-methyl)T-TTTTTCTTC)-3' + H2O for 2'-O-methyl-T modified antisense oligonucleotide 6 degradation goes faster with respect to the antisense oligonucleotides 2-5 Crotalus adamanteus ?
-
?
5'-(dCTTCA-(2'-oxetane)T-TTTTTCTTC)-3' + H2O
-
Crotalus adamanteus ?
-
?
5'-(dCTTCATT-(2'-azetidine)T-TTTCTTC)-3' + H2O azetidine-T modified antisense oligonucleotide 10 degradation goes faster with respect to the antisense oligonucleotides 2-5 Crotalus adamanteus ?
-
?
5'-(dCTTCATT-(2'-N-4'-C-ethylene-bridged)T-TTTCTTC)-3' + H2O 2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 4 still remains undegraded to certain extent Crotalus adamanteus ?
-
?
5'-(dCTTCATTTT-(2'-azetidine)T-TCTTC)-3' + H2O azetidine-T modified antisense oligonucleotide 8 degradation goes faster with respect to the antisense oligonucleotides 2-5 Crotalus adamanteus ?
-
?
5'-(dCTTCATTTT-(2'-N-4'-C-ethylene-bridged)T-TCTTC)-3' + H2O 2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 3 still remains undegraded to certain extent Crotalus adamanteus ?
-
?
5'-(dCTTCATTTTTTC-(2'-azetidine)T-TC)-3' + H2O azetidine-T modified antisense oligonucleotide 8 still remains undegraded to certain extent Crotalus adamanteus ?
-
?
5'-(dCTTCATTTTTTC-(2'-N-4'-C-ethylene-bridged)T-TC)-3' + H2O 2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 2 still remains undegraded to certain extent Crotalus adamanteus ?
-
?
5'-(dCTTCATTTTTTCTTC)-3' + H2O unmodified antisense oligonucleotide 1 is completely degraded after 30 min Crotalus adamanteus ?
-
?

Synonyms

Synonyms Comment Organism
3'-exonuclease
-
Crotalus adamanteus
snake venom phosphodiesterase
-
Crotalus adamanteus
SVPDE
-
Crotalus adamanteus