Cloned (Comment) | Organism |
---|---|
expressed as N-terminal His6-tagged polypeptide in Escherichia coli BL21(DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl) cytosine | - |
Homo sapiens | |
1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N4-benzoyl cytosine | - |
Homo sapiens | |
9-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N6-benzoyl adenine | - |
Homo sapiens | |
AMP | - |
Homo sapiens | |
CMP | - |
Homo sapiens | |
synthetic fluoro-pyranosyl nucleosides | synthetic nucleoside analogues bearing a fluoroglucopyranosyl sugar moiety and benzoyl-modified cytosine or adenine as a base can effectively inhibit human PARN | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
74000 | - |
calculated | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95453 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(A) + H2O | - |
Homo sapiens | AMP | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
PARN | - |
Homo sapiens |
poly(A)-specific ribonuclease | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.21 | - |
1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N4-benzoyl cytosine | at pH 7.0, 30°C | Homo sapiens | |
0.51 | - |
9-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N6-benzoyl adenine | at pH 7.0, 30°C | Homo sapiens | |
0.645 | - |
1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl) cytosine | at pH 7.0, 30°C | Homo sapiens | |
0.7 | - |
CMP | at pH 7.0, 30°C | Homo sapiens | |
1.6 | - |
AMP | at pH 7.0, 30°C | Homo sapiens |