Literature summary for 3.1.13.2 extracted from

Marchand, C.; Beutler, J.A.; Wamiru, A.; Budihas, S.; Moellmann, U.; Heinisch, L.; Mellors, J.W.; Le Grice, S.F.; Pommier, Y.
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H (2008), Antimicrob. Agents Chemother., 52, 361-364.

Inhibitors

Inhibitors	Comment	Organism
(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)acetic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-3-[(E)-{[(2-hydroxyphenyl)carbonyl]hydrazono}methyl]-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-3-[(E)-{[(4-methylphenyl)sulfonyl]hydrazono}methyl]-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-3-{(E)-[(4-nitrophenyl)hydrazono]methyl}-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-3-(1,2,3,4-tetrahydroquinazolin-2-yl)-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-3-[(E)-(tetracyclo[5.3.1.03,9.05,9]undec-1-ylimino)methyl]-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-3-{(E)-[(phenylcarbonyl)hydrazono]methyl}-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2,3-dicarboxylic acid	-	Human immunodeficiency virus 1
1,9,11,14-tetrahydroxy-7-methoxy-3-[(E)-(methoxyimino)methyl]-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazine-2(1H)-carboximidamide	-	Human immunodeficiency virus 1
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-2,3,4,4a,6,7-hexahydropyrimido[2,1-a]tetraceno[1,2-f]isoindole-9,14,17(1H)-trione	-	Human immunodeficiency virus 1
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-2-phenyl-6,7-dihydrotetraceno[1,2-g]phthalazine-1,9,14(2H)-trione	-	Human immunodeficiency virus 1
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-2-propyl-6,7-dihydrotetraceno[1,2-g]phthalazine-1,9,14(2H)-trione	-	Human immunodeficiency virus 1
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-6,7-dihydrotetraceno[1,2-g]phthalazine-1,9,14(2H)-trione	-	Human immunodeficiency virus 1
12,14,17,18-tetrahydroxy-10-methoxy-13-methyl-6,6a,8,9-tetrahydrotetraceno[1',2':5,6]isoindolo[2,1-a]quinazoline-11,16,19(5H)-trione	-	Human immunodeficiency virus 1
15,16-dihydroxy-8-methoxy-12-[(methoxycarbonyl)oxy]-11-methyl-1,9,14-trioxo-2-propyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazin-10-yl acetate	-	Human immunodeficiency virus 1
2,4,17,18-tetrahydroxy-6-methoxy-3-methyl-7,9b-dihydrotetraceno[1',2':5,6]isoindolo[1,2-b][1,3]benzothiazole-5,16,19(8H)-trione	-	Human immunodeficiency virus 1
2-(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)ethyl acetate	-	Human immunodeficiency virus 1
3,9,11,14,15-pentahydroxy-7-methoxy-N,N,N,10-tetramethyl-1,8,13-trioxo-1,3,5,6,8,13-hexahydro-2H-tetraceno[1,2-f]isoindol-2-aminium	-	Human immunodeficiency virus 1
3-[(E)-(carbamimidoylhydrazono)methyl]-1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
3-[(E)-(tert-butylhydrazono)methyl]-1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid	-	Human immunodeficiency virus 1
4-(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)benzoic acid	-	Human immunodeficiency virus 1
8-methoxy-11-methyl-1,9,14-trioxo-2-phenyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazine-10,12,15,16-tetrayl tetraacetate	-	Human immunodeficiency virus 1
8-methoxy-11-methyl-1,9,14-trioxo-2-propyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazine-10,12,15,16-tetrayl tetraacetate	-	Human immunodeficiency virus 1
9,11,14,15-tetrahydroxy-7-methoxy-10-methyl-8,13,16-trioxo-1,2,3a,5,6,8,13,16-octahydrotetraceno[1,2-f][1,3]thiazolo[2,3-a]isoindole-1-carboxylic acid	-	Human immunodeficiency virus 1
ethyl 3-(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)propanoate	-	Human immunodeficiency virus 1
madurahydroxylactone	a secondary metabolite from the soil bacterium Nonomuraea rubra, belonging to the family of benzo[a]naphthacenequinone antibiotics	Human immunodeficiency virus 1
methyl 10,15,16-trihydroxy-8-methoxy-11-methyl-1,9,14-trioxo-2-phenyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazin-12-yl carbonate	-	Human immunodeficiency virus 1
[10,12,15,16-tetrakis(cyclohexyloxy)-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl]acetic acid	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	i.e. HIV-1	-

Synonyms

Synonyms	Comment	Organism
RNase H	-	Human immunodeficiency virus 1