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Literature summary for 3.1.13.2 extracted from

  • Schultz, S.J.; Zhang, M.; Champoux, J.J.
    Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H (2006), J. Biol. Chem., 281, 1943-1955.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Moloney murine leukemia virus the enzyme is essential for retroviral replication ?
-
 ?
additional information Human immunodeficiency virus 1 the enzyme is essential for retroviral replication ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-
Moloney murine leukemia virus
-
 i.e. M-MuLV
-

Reaction

Reaction Comment Organism Reaction ID
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid the selection of 5'-end-directed cleavage sites by the retroviral RNase H results from a combination of nucleotide sequence, permissible distance, and accessibility to the RNA 5'-end Moloney murine leukemia virus
a
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid the selection of 5'-end-directed cleavage sites by the retroviral RNase H results from a combination of nucleotide sequence, permissible distance, and accessibility to the RNA 5'-end Human immunodeficiency virus 1
a

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Moloney murine leukemia virus
-
commercial preparation recombinant enzyme Human immunodeficiency virus 1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O cleavage site recognition and specificity, mechanism, in vitro synthesis of substrates, overview Moloney murine leukemia virus ?
-
 ?
DNA-RNA hybrid + H2O cleavage site recognition and specificity, mechanism, in vitro synthesis of substrates, overview Human immunodeficiency virus 1 ?
-
 ?
additional information the enzyme is essential for retroviral replication Moloney murine leukemia virus ?
-
 ?
additional information the enzyme is essential for retroviral replication Human immunodeficiency virus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme is part of the viral reverse transcriptase Moloney murine leukemia virus
More the enzyme is part of the viral reverse transcriptase Human immunodeficiency virus 1
retroviral RNase H
-
 Moloney murine leukemia virus
retroviral RNase H
-
 Human immunodeficiency virus 1