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Literature summary for 3.1.13.2 extracted from

  • Somasunderam, A.; Ferguson, M.R.; Rojo, D.R.; Thiviyanathan, V.; Li, X.; O'Brien, W.A.; Gorenstein, D.G.
    Combinatorial selection, inhibition, and antiviral activity of DNA thioaptamers targeting the RNase H domain of HIV-1 reverse transcriptase (2005), Biochemistry, 44, 10388-10395.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.2

Application

Application Comment Organism
pharmacology the enzyme is a target for therapeutic antiviral drug development, design, by combinatorial selection, of dsDNA thioaptamers with selected thiophosphate backbone substitutions inhibiting the RNase activity of the reverse transcriptase and the viral replication, overview Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
additional information design of diverse dsDNA thioaptamers with selected thiophosphate backbone substitutions effectively inhibiting the RNase activity of the reverse transcriptase and the viral replication, i.e. thioadaptamer R12-2 or XBY-S2, overview Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human immunodeficiency virus 1 the enzyme plays a key role in viral proliferation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O substrate preparation, overview Human immunodeficiency virus 1 ?
-
 ?
additional information the enzyme plays a key role in viral proliferation Human immunodeficiency virus 1 ?
-
 ?
additional information the enzyme is part of the viral reverse transcriptase Human immunodeficiency virus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme is part of the viral reverse transcriptase Human immunodeficiency virus 1
ribonuclease H
-
 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 1

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Human immunodeficiency virus 1

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Human immunodeficiency virus 1