Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,7-dihydroxytropolones | - |
Human immunodeficiency virus 1 | |
additional information | no inhibition by O-methylated 3,7-dihydroxytropolones and tropolones, IC50 values, overview | Human immunodeficiency virus 1 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 1-2 ions are required for RNase H and integrase activities of the reverse transcriptase, 2 different Mg2+ ions are required for polymerase activity and are loacted in the polymerase active site of the reverse transcriptase, 3,7-dihydroxytropolone inhibitors target the Mg2+ ions, overview | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-RNA hybrid + H2O | - |
Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the reverse transcriptase possesses different activity domains and shows RNase H, integrase, and DNA polymerase activities | Human immunodeficiency virus 1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme is part of the viral reverse transcriptase, cf. EC 2.7.7.49, RNA-directed DNA-polymerase | Human immunodeficiency virus 1 |
ribonuclease H | - |
Human immunodeficiency virus 1 |
RNase H | - |
Human immunodeficiency virus 1 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Human immunodeficiency virus 1 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Human immunodeficiency virus 1 |