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Literature summary for 3.1.13.1 extracted from

  • Ning Kwan, C.
    A cytoplasmic exoribonuclease from HeLa cells (1977), Biochim. Biophys. Acta, 479, 322-331.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NaCl a salt concentration of 0.05 M inhibits 50% of the activity, salt optimum: 0.01 M Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ necessary for activity Homo sapiens
Mg2+ optimum: 1 mM Homo sapiens
Mn2+ can partially replace Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ss RNA + H2O Homo sapiens
-
5'-phosphomononucleotides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification, 500-700fold Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates acts in a processive manner Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.004
-
substrate: poly(A) Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ds RNA is not hydrolyzed Homo sapiens ?
-
?
additional information ds DNA is not hydrolyzed Homo sapiens ?
-
?
mRNA + H2O
-
Homo sapiens 5'-phosphomononucleotides
-
?
poly(A) + H2O
-
Homo sapiens 5'-AMP + oligonucleotide
-
?
poly(C) + H2O
-
Homo sapiens 5'-CMP + oligonucleotide
-
?
ss RNA + H2O
-
Homo sapiens 5'-phosphomononucleotides
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
for 1 min completely destroys enzyme activity Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
NaCl salt 0.01 M Homo sapiens