Literature summary for 3.1.11.5 extracted from

Arnold, D.A.; Kowalczykowski, S.C.
Facilitated loading of RecA protein is essential to recombination by RecBCD enzyme (2000), J. Biol. Chem., 275, 12261-12265.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the mutant RecB2109CD degrades the double-stranded DNA primarily in the 5 to 3 direction, producing processed double-stranded DNA with a 3-terminal overhang, the mutant is unable to coordinate the loading of RecA protein onto the single-stranded DNA produced, this inability can be responsible for recB2109 recombination defect observed in vivo	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	the nuclease activities of wild-type enzyme is sensitive to the concentration of free magnesium ions in solution	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	the RecA protein loading is an essential function of the enzyme	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P08394	RecB2109 gene	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the RecA protein loading is an essential function of the enzyme	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)