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Literature summary for 3.1.11.3 extracted from
- Lambda exonuclease digestion of CGG trinucleotide repeats (2010), Eur. Biophys. J., 39, 337-343.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | initiates DNA digestion | synthetic construct |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| synthetic construct | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| double-stranded DNA + H2O | sequence-dependent rate and pausing of individual lambda exonuclease enzymes during the digestion of a DNA sequence containing 120 CGG repeats. GC-rich repetitive sequences provide a significant barrier to lambda exonuclease activity by increasing the probability of pausing in addition to reducing the average digestion rate | synthetic construct | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lambda exonuclease | - |
synthetic construct |
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Release 2023.1 (January 2023)
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