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Literature summary for 3.1.11.2 extracted from

  • Abeldenov, S.; Talhaoui, I.; Zharkov, D.O.; Ishchenko, A.A.; Ramanculov, E.; Saparbaev, M.; Khassenov, B.
    Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis (2015), DNA Repair, 33, 1-16 .
    View publication on PubMed
Search for more literature for 3.1.11.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme requires the presence of Mg2+ and, to lesser extent, Ca2+ and Mn2+ for the DNA repair activity Mycobacterium tuberculosis
Mg2+ the enzyme requires the presence of Mg2+ and, to lesser extent, Ca2+ and Mn2+ for the DNA repair activity Mycobacterium tuberculosis
Mn2+ the enzyme requires the presence of Mg2+ and, to lesser extent, Ca2+ and Mn2+ for the DNA repair activity. Depending on pH, the enzyme requires different concentrations of divalent cations: 0.5 mM MnCl2 at pH 7.6 and 10 mM at pH 6.5 Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P96273
-
-
Mycobacterium tuberculosis H37Rv P96273
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
exonuclease III
-
 Mycobacterium tuberculosis
MtbXthA
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function key enzyme involved in the repair of abasic sites and DNA strand breaks Mycobacterium tuberculosis