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Literature summary for 3.1.11.2 extracted from

  • Fromenty, B.; Demeilliers, C.; Mansouri, A.; Pessayre, D.
    Escherichia coli exonuclease III enhances long PCR amplification of damaged DNA templates (2000), Nucleic Acids Res., 28; e50, ii-vii.
No PubMed abstract available

Application

Application Comment Organism
medicine study of a novel strategy using enzyme for direct sequencing of double-stranded DNA by MALDI-TOF mass spectroscopy Escherichia coli
medicine the enzyme is helpful for PCR amplification of long DNA templates Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Reaction

Reaction Comment Organism Reaction ID
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates four activities of enzyme: 3’-5’ exonuclease, RNase H, 3’-phosphatase and AP endonuclease Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
double-stranded DNA + H2O the enzyme degrades the phosphodiester bond from the 3’ end of double-stranded DNA Escherichia coli deoxynucleoside 5'-phosphate
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