Literature summary for 3.1.11.2 extracted from

Shokolenko, I.N.; Alexeyev, M.F.; Robertson, F.M.; LeDoux, S.P.; Wilson, G.L.
The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress (2003), DNA Repair, 2, 471-482.

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Cloned(Commentary)

Cloned (Comment)	Organism
the enzyme containing the mitochondrial targeting signal of manganese superoxide dismutase is expressed in a human malignant breast epithelial cell line, MDA-MB-231, this expression results in a decrease in cell viability following exposure to oxidative stress	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	the enzyme is a major AP endonuclease activity that is involved in efficient repair of oxidative lesions in bacterial DNA	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is a major AP endonuclease activity that is involved in efficient repair of oxidative lesions in bacterial DNA	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)