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Literature summary for 3.1.11.1 extracted from

  • Keijzers, G.; Liu, D.; Rasmussen, L.
    Exonuclease 1 and its versatile roles in DNA repair (2016), Crit. Rev. Biochem. Mol. Biol., 51, 440-451 .
No PubMed abstract available
Search for more literature for 3.1.11.1

Activating Compound

Activating Compound Comment Organism Structure
14-3-3 isoform eta
-
 Homo sapiens
14-3-3 isoform sigma
-
 Homo sapiens
proliferating cell nuclear antigen
-
 Homo sapiens

General Stability

General Stability Organism
ultraviolet C radiation, ionizing radiation, cisplatin and methylnitronitrosoguanidine do not affect the stability of the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicked DNA containing mismatches + H2O Homo sapiens
-
 ?
-
 ?
single-stranded oligodeoxyribonucleotide + H2O Homo sapiens
-
 single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
 ?
ssDNA + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UQ84
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens
ubiquitination
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicked DNA containing mismatches + H2O
-
 Homo sapiens ?
-
 ?
single-stranded oligodeoxyribonucleotide + H2O
-
 Homo sapiens single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
 ?
ssDNA + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Exo1
-
 Homo sapiens
exonuclease 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme mutations correlate with increased susceptibility to some cancers Homo sapiens
metabolism exonuclease 1 is a multifunctional 5'->3' exonuclease and a DNA structure-specific DNA endonuclease Homo sapiens
physiological function the enzyme plays roles in telomere maintenance, DNA replication, DNA mismatch repair and DNA double-stranded break repair and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining Homo sapiens