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Literature summary for 3.1.11.1 extracted from
- Human exonuclease 1 (EXO1) activity characterization and its function on flap structures (2015), Biosci. Rep., 35, e00206 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UQ84 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 42mer double stranded DNA containing mismatches + H2O | the enzyme has a strong capacity for degrading double stranded DNA | Homo sapiens | ? | - |
? |  |
| forked and nicked dsDNA containing mismatches + H2O | the enzyme preferentially cleaves one nucleotide inwards in a double stranded region of a forked and nicked DNA flap substrates | Homo sapiens | ? | - |
? | |
| additional information | the enzyme has a modest endonuclease or 5' flap activity | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 120000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Exo1 | - |
Homo sapiens |
| exonuclease 1 | - |
Homo sapiens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 37 | the enzyme has approximately a 2fold increase in enzymatic activity at 25°C and 30°C compared with 37°C | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
the enzyme is inactive in reaction mixture after 10 min at 37°C | Homo sapiens |
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