Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 3' G4 telomeric tails inhibit Flap cleavage by human exonuclease 1, but not by human endonuclease 1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Exo1 | - |
Homo sapiens |
exonuclease 1 | - |
Homo sapiens |
More | exonuclease 1 is a member of the RAD2 family of structure-specific nucleases | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | comparison of exonuclease 1, EXO1, and Flap endonuclease 1, FEN1, activities on G4 DNA substrates, hFEN1, but not hEXO1, cleaves 59 telomeric G4 DNA, overview. Telomeres are composed of G-rich repeats that readily form G4 DNA. human EXO1 and FEN1 exhibit distinct activities on G4 DNA substrates representative of intermediates in immunoglobulin class switch recombination, distinct telomeric phenotypes caused by EXO1 and FEN1 deficiencies, overview | Homo sapiens |