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Literature summary for 3.1.11.1 extracted from

  • Vallur, A.C.; Maizels, N.
    Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats (2010), J. Biol. Chem., 285, 28514-28519.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.11.1

Cloned(Commentary)

Cloned (Comment) Organism
expression of hEXO1 in Spodoptera frugiperda Sf9 insect cells using the baculovirus vector system Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
K+ required Homo sapiens
Mg2+ required Homo sapiens
Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens hEXO1 does not exhibit endonuclease activity on 5'-flaps bearing structures formed by CTG or CGG repeats, although it can excise these substrates. hEXO1 is not affected by the stem-loops formed by CTG repeats interrupting duplex regions adjacent to 5'-flaps, but the enzymes is inhibited by G4 structures formed by CGG repeats in analogous positions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hEXO1 does not exhibit endonuclease activity on 5'-flaps bearing structures formed by CTG or CGG repeats, although it can excise these substrates. hEXO1 is not affected by the stem-loops formed by CTG repeats interrupting duplex regions adjacent to 5'-flaps, but the enzymes is inhibited by G4 structures formed by CGG repeats in analogous positions Homo sapiens ?
-
 ?
additional information hEXO1 exhibits both flap endonucleolytic cleavage activity and exonucleolytic activity on the substrates carrying a duplex region or a duplex region interrupted by a (CTG)8 repeat, but not on the substrate in which a (CGG)6 repeat interrupted the duplex Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Exo1
-
 Homo sapiens
exonuclease 1
-
 Homo sapiens
More EXO1 belongs to the RAD2 family nucleases, FEN1 (Flap endonuclease 1) and EXO1 (exonuclease 1) Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function EXO1 can eliminate structures formed by trinucleotide repeats in the course of DNA replication Homo sapiens