Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | human EXO1 excision depends on the presence of a G loop, requires a nick and depends on transcription and transcriptional orientation | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | EXO1 can function as either an exonuclease or flap endonuclease on switch substrates. Model for exonuclease 1 function in class switch recombination, in which cleavage at activation-induced deaminase (AID)-initiated nicks produces gaps that become substrates for further attack by AID and subsequent repair | Homo sapiens |
additional information | model for exonuclease 1 function in class switch recombination, in which cleavage at activation-induced deaminase (AID)-initiated nicks produces gaps that become substrates for further attack by AID and subsequent repair | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in insect Sf9 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | switch junction position is altered in Exo1-/- mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | robust cleavage of transcribed G-rich DNA sequences with potential to form G loops and G4 DNA. Predicted immunoglobulin switch recombination intermediates are substrates for both exonucleolytic and 5' flap endonucleolytic cleavage | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Exo1 | - |
Mus musculus |
Exo1 | - |
Homo sapiens |
exonuclease 1 | - |
Mus musculus |
exonuclease 1 | - |
Homo sapiens |