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Literature summary for 3.1.11.1 extracted from

  • Vallur, A.C.; Maizels, N.
    Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions (2008), Proc. Natl. Acad. Sci. USA, 105, 16508-16512.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information human EXO1 excision depends on the presence of a G loop, requires a nick and depends on transcription and transcriptional orientation Homo sapiens

Application

Application Comment Organism
additional information EXO1 can function as either an exonuclease or flap endonuclease on switch substrates. Model for exonuclease 1 function in class switch recombination, in which cleavage at activation-induced deaminase (AID)-initiated nicks produces gaps that become substrates for further attack by AID and subsequent repair Homo sapiens
additional information model for exonuclease 1 function in class switch recombination, in which cleavage at activation-induced deaminase (AID)-initiated nicks produces gaps that become substrates for further attack by AID and subsequent repair Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in insect Sf9 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information switch junction position is altered in Exo1-/- mice Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information robust cleavage of transcribed G-rich DNA sequences with potential to form G loops and G4 DNA. Predicted immunoglobulin switch recombination intermediates are substrates for both exonucleolytic and 5' flap endonucleolytic cleavage Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Exo1
-
Mus musculus
Exo1
-
Homo sapiens
exonuclease 1
-
Mus musculus
exonuclease 1
-
Homo sapiens