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Literature summary for 3.1.11.1 extracted from
- ATR-dependent pathways control hEXO1 stability in response to stalled forks (2008), Nucleic Acids Res., 36, 511-519.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | analysis of single- and multiple-point mutants reveals that mutation to Ala of the three hydroxyurea-induced sites of phosphorylation partially rescues hydroxyurea-dependent degradation of hEXO1 and additionally stabilizes the protein in non-treated cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UQ84 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | human exonuclease 1 is phosphorylated in response to agents stalling DNA replication. hEXO1 phosphorylation is ATR-dependent. hEXO1 is phosphorylated at nine basal sites and three additional sites are induced by hydroxyurea treatment | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| exonuclease 1 | - |
Homo sapiens |
| hEXO1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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