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Literature summary for 3.1.11.1 extracted from

  • Bardwell, P.D.; Woo, C.J.; Wei, K.; Li, Z.; Martin, A.; Sack, S.Z.; Parris, T.; Edelmann, W.; Scharff, M.D.
    Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice (2004), Nat. Immunol., 5, 224-229.
    View publication on PubMed
Search for more literature for 3.1.11.1

Protein Variants

Protein Variants Comment Organism
additional information construction of enzyme-deficient mutant mice which show a deficient humoral response and immunoglobulin switching defects, the mutant mice show altered patterns of somatic hypermutation, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing mismatches + H2O Mus musculus the enzyme is involved in mismatch repair and participates directly in somatic hypermutation and class-switch recombination ?
-
 ?
additional information Mus musculus the enzyme is associated to Mlh1 and binds to mutating V regions of DNA in BL2 cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates the enzyme is involved in mismatch repair and participates directly in somatic hypermutation and class-switch recombination Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
BL-2 cell Burkitt's lymphoma cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing mismatches + H2O the enzyme is involved in mismatch repair and participates directly in somatic hypermutation and class-switch recombination Mus musculus ?
-
 ?
DNA containing mismatches + H2O the enzyme is involved in mismatch repair Mus musculus ?
-
 ?
additional information the enzyme is associated to Mlh1 and binds to mutating V regions of DNA in BL2 cells Mus musculus ?
-
 ?
additional information the enzyme is associated to Mlh1 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
exonuxlease 1
-
 Mus musculus