Application | Comment | Organism |
---|---|---|
medicine | in a xenograft model of endometrial cancer, covalent PME-1 inhibitors decrease cell proliferation and invasive growth in vitro but have no effect in vivo at the concentrations tested. Depletion of PME-1 with shRNA in an endometrial cancer xenograft model significantly reduces tumor growth | Homo sapiens |
pharmacology | RNAi and pharmacologic inhibition of PME-1 in vitro leads to decreased cell proliferation and invasive growth in endometrial cancer cells. Discovery of more potent PME-1 inhibitors may be beneficial for the treatment of endometrial cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ABL-127 | - |
Homo sapiens | |
AMZ-30 | - |
Homo sapiens | |
DMSO | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[phosphatase 2A protein]-leucine methyl ester + H2O | Homo sapiens | - |
[phosphatase 2A protein]-leucine + methanol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y570 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ishikawa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[phosphatase 2A protein]-leucine methyl ester + H2O | - |
Homo sapiens | [phosphatase 2A protein]-leucine + methanol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PME-1 | - |
Homo sapiens |
PPME1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | protein methylesterase 1 (PME-1) promotes cancerous phenotypes through the demethylation and inactivation of protein phosphatase 2A | Homo sapiens |