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Literature summary for 3.1.1.89 extracted from

  • Pusey, M.; Bail, S.; Xu, Y.; Buiakova, O.; Nestor, M.; Yang, J.J.; Rice, L.M.
    Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models (2016), Tumour Biol., 37, 11835-11842 .
    View publication on PubMed

Application

Application Comment Organism
medicine in a xenograft model of endometrial cancer, covalent PME-1 inhibitors decrease cell proliferation and invasive growth in vitro but have no effect in vivo at the concentrations tested. Depletion of PME-1 with shRNA in an endometrial cancer xenograft model significantly reduces tumor growth Homo sapiens
pharmacology RNAi and pharmacologic inhibition of PME-1 in vitro leads to decreased cell proliferation and invasive growth in endometrial cancer cells. Discovery of more potent PME-1 inhibitors may be beneficial for the treatment of endometrial cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ABL-127
-
Homo sapiens
AMZ-30
-
Homo sapiens
DMSO
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[phosphatase 2A protein]-leucine methyl ester + H2O Homo sapiens
-
[phosphatase 2A protein]-leucine + methanol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y570
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Ishikawa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[phosphatase 2A protein]-leucine methyl ester + H2O
-
Homo sapiens [phosphatase 2A protein]-leucine + methanol
-
?

Synonyms

Synonyms Comment Organism
PME-1
-
Homo sapiens
PPME1
-
Homo sapiens

General Information

General Information Comment Organism
metabolism protein methylesterase 1 (PME-1) promotes cancerous phenotypes through the demethylation and inactivation of protein phosphatase 2A Homo sapiens