Literature summary for 3.1.1.89 extracted from

Tian, H.; Lu, Y.; Liu, J.; Liu, W.; Lu, L.; Duan, C.; Gao, G.; Yang, H.
Leucine carboxyl methyltransferase downregulation and protein phosphatase methylesterase upregulation contribute toward the inhibition of protein phosphatase 2A by alpha-synuclein (2018), Front. Aging Neurosci., 10, 173 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
AMZ30	PME-1 inhibition by AMZ30 protects against PP2A inactivation and cell apoptosis mediated by alpha-syn	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BVQ5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PME-1	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	PP2A demethylation is accompanied by upregulated PME-1 expression. alpha-Synuclein increases demethylation of protein phosphatase 2A via downregulation of leucine carboxyl methyltransferase (LCMT-1) expression, and upregulation of protein phosphatase methylesterase PME-1 expression	up

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Release 2023.1 (January 2023)