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Literature summary for 3.1.1.89 extracted from

  • Yabe, R.; Tsuji, S.; Mochida, S.; Ikehara, T.; Usui, T.; Ohama, T.; Sato, K.
    A stable association with PME-1 may be dispensable for PP2A demethylation - implications for the detection of PP2A methylation and immunoprecipitation (2018), FEBS open bio, 8, 1486-1496 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[phosphatase 2A protein]-leucine methyl ester + H2O Mus musculus reversible methyl-esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme [phosphatase 2A protein]-leucine + methanol
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r

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BVQ5
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[phosphatase 2A protein]-leucine methyl ester + H2O reversible methyl-esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme Mus musculus [phosphatase 2A protein]-leucine + methanol
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r
[phosphatase 2A protein]-leucine methyl ester + H2O the enzyme specifically catalyzes PP2Ac demethylation Mus musculus [phosphatase 2A protein]-leucine + methanol
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r

Synonyms

Synonyms Comment Organism
PME-1
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Mus musculus