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Literature summary for 3.1.1.89 extracted from

  • Hombauer, H.; Weismann, D.; Mudrak, I.; Stanzel, C.; Fellner, T.; Lackner, D.H.; Ogris, E.
    Generation of active protein phosphatase 2A is coupled to holoenzyme assembly (2007), PLoS Biol., 5, e155.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Synonyms

Synonyms Comment Organism
PPE1
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function maturation of C subunit of substrate protein phosphatase 2A is under the surveillance of the enzyme, PP2A methylesterase PPE1, which upon malfunction of PP2A biogenesis, prevents premature generation of the active C subunit and holoenzyme assembly by counteracting the untimely methylation of the C subunit. Deletion of PPE1 decreases the levels of trimeric complexes of protein phosphatase 2A activator RRD2, structural subunit TPD3 and C subunit Saccharomyces cerevisiae