Literature summary for 3.1.1.84 extracted from

Collins, G.T.; Brim, R.L.; Narasimhan, D.; Ko, M.C.; Sunahara, R.K.
Zhan. C.G.; Woods. J.H.: Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats (2009), J. Pharmacol. Exp. Ther., 331, 445-455.

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Application

Application	Comment	Organism
medicine	a series of experiments demonstrates the capacity of the longer acting mutant, CocE T172R/G173Q, to provide a long-lasting protection against cocaine-induced convulsion and lethality, and a dose-dependent and selective inhibition the ongoing self-administration of cocaine in rats. Potential usefulness of a suitable, stable, and long-acting form of CocE as a pharmacotherapy for cocaine abuse in humans	Rhodococcus sp.

Protein Variants

Protein Variants	Comment	Organism
T172R/G173Q	mutant enzyme with increased half-life	Rhodococcus sp.

Organism

Organism	UniProt	Comment	Textmining
Rhodococcus sp.	Q9L9D7	-	-

Synonyms

Synonyms	Comment	Organism
cocE	-	Rhodococcus sp.

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Release 2023.1 (January 2023)