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Literature summary for 3.1.1.81 extracted from

  • Mei, G.Y.; Yan, X.X.; Turak, A.; Luo, Z.Q.; Zhang, L.Q.
    AidH, an alpha/beta-hydrolase fold family member from an Ochrobactrum sp. strain, is a novel N-acylhomoserine lactonase (2010), Appl. Environ. Microbiol., 76, 4933-4942.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.81

Protein Variants

Protein Variants Comment Organism
E219T the mutant is active at wild type levels Ochrobactrum sp. T63
G100V inactive Ochrobactrum sp. T63
G104V inactive Ochrobactrum sp. T63
H248S inactive Ochrobactrum sp. T63
S102V inactive Ochrobactrum sp. T63

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ the N-acyl-(S)-homoserine lactone-inactivating activity of the enzyme requires Mn2+ Ochrobactrum sp. T63
additional information not affected by Ca2+, Mg2+, Cu2+, Fe2+, Zn2+ Ochrobactrum sp. T63

Organism

Organism UniProt Comment Textmining
Ochrobactrum sp. T63 D2J2T6
-
-
Ochrobactrum sp. T63 ATCC 49188 D2J2T6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acyl-(S)-homoserine lactone + H2O
-
 Ochrobactrum sp. T63 N-acyl-(S)-homoserine
-
 ?
N-acyl-(S)-homoserine lactone + H2O
-
 Ochrobactrum sp. T63 ATCC 49188 N-acyl-(S)-homoserine
-
 ?

Synonyms

Synonyms Comment Organism
AHL-lactonase
-
 Ochrobactrum sp. T63
AidH
-
 Ochrobactrum sp. T63
N-acylhomoserine lactonase
-
 Ochrobactrum sp. T63

General Information

General Information Comment Organism
physiological function the enzyme significantly reduces biofilm formation by Pseudomonas fluorescens strain 2P24 and the pathogenicity of Pectobacterium carotovorum indicating that this enzyme is able to effectively quench quorum-sensing-dependent functions in these bacteria by degrading N-acyl-(S)-homoserine lactones Ochrobactrum sp. T63