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Literature summary for 3.1.1.81 extracted from

  • Yang, F.; Wang, L.H.; Wang, J.; Dong, Y.H.; Hu, J.Y.; Zhang, L.H.
    Quorum quenching enzyme activity is widely conserved in the sera of mammalian species (2005), FEBS Lett., 579, 3713-3717.
    View publication on PubMed
Search for more literature for 3.1.1.81

Inhibitors

Inhibitors Comment Organism Structure
EDTA in vitro and in serum Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, required Mus musculus
Ca2+ activates, required Homo sapiens
Ca2+ activates, required Bos taurus
Ca2+ activates, required Oryctolagus cuniculus
Ca2+ activates, required Capra hircus
Ca2+ activates, required Equus caballus
additional information no activation by Mg2+, Mn2+, Fe2+, Zn2+, Co2+, Cu2+, and Pb2+ Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lacton ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Mus musculus acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Homo sapiens acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Bos taurus acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Capra hircus acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Equus caballus acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Capra hircus aiiA acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Mus musculus aiiA acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Oryctolagus cuniculus aiiA acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lacton ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Homo sapiens aiiA acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Bos taurus aiiA acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
additional information Equus caballus aiiA acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme ?
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Mus musculus
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Homo sapiens
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Bos taurus
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Oryctolagus cuniculus
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Capra hircus
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Equus caballus
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Capra hircus aiiA
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Mus musculus aiiA
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Oryctolagus cuniculus aiiA
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Homo sapiens aiiA
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Bos taurus aiiA
-
 N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O Equus caballus aiiA
-
 N-3-oxododecanoyl-L-homoserine
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 aiiA
-
Bos taurus aiiA
-
 aiiA
-
Capra hircus
-
 aiiA
-
Capra hircus aiiA
-
 aiiA
-
Equus caballus
-
 aiiA
-
Equus caballus aiiA
-
 aiiA
-
Homo sapiens
-
 aiiA
-
Homo sapiens aiiA
-
 aiiA
-
Mus musculus
-
 aiiA
-
Mus musculus aiiA
-
 aiiA
-
no activity in Gallus gallus
-
-
-
Oryctolagus cuniculus
-
 aiiA
-
Oryctolagus cuniculus aiiA
-
 aiiA
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Mus musculus
-
serum
-
 Homo sapiens
-
serum
-
 Bos taurus
-
serum
-
 Oryctolagus cuniculus
-
serum
-
 Capra hircus
-
serum
-
 Equus caballus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.012
-
 serum Homo sapiens
0.013
-
 serum Bos taurus
0.013
-
 serum Capra hircus
0.014
-
 serum Equus caballus
0.016
-
 serum Mus musculus
0.017
-
 serum, substrate N-3-oxododecanoyl-L-homoserine lactone Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lacton ring thus acting as quorum-quenching enzyme Oryctolagus cuniculus ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Mus musculus ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Homo sapiens ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Bos taurus ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Capra hircus ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Equus caballus ?
-
 ?
additional information substrate specificity, N-butanoyl-L-homoserine lactone is a poor substrate Oryctolagus cuniculus ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Capra hircus aiiA ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Mus musculus aiiA ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lacton ring thus acting as quorum-quenching enzyme Oryctolagus cuniculus aiiA ?
-
 ?
additional information substrate specificity, N-butanoyl-L-homoserine lactone is a poor substrate Oryctolagus cuniculus aiiA ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Homo sapiens aiiA ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Bos taurus aiiA ?
-
 ?
additional information acyl-homoserine lactone quorum-sensing signals play a key role in synchronizing virulence gene expression during bloodstream infections of mammals, the enzyme inactivates the AHL signaling by hydrolysis of the lactone ring thus acting as quorum-quenching enzyme Equus caballus aiiA ?
-
 ?
N-3-oxodecanoyl-L-homoserine lactone + H2O high activity Oryctolagus cuniculus N-3-oxodecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Mus musculus N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Homo sapiens N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Bos taurus N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Capra hircus N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Equus caballus N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O best substrate Oryctolagus cuniculus N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Capra hircus aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Mus musculus aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O best substrate Oryctolagus cuniculus aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Homo sapiens aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Bos taurus aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxododecanoyl-L-homoserine lactone + H2O
-
 Equus caballus aiiA N-3-oxododecanoyl-L-homoserine
-
 ?
N-3-oxohexanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus N-3-oxohexanoyl-L-homoserine
-
 ?
N-3-oxooctanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus N-3-oxooctanoyl-L-homoserine
-
 ?
N-3-oxooctanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus aiiA N-3-oxooctanoyl-L-homoserine
-
 ?
N-decanoyl-L-homoserine lactone + H2O high activity Oryctolagus cuniculus N-decanoyl-L-homoserine
-
 ?
N-hexanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus N-hexanoyl-L-homoserine
-
 ?
N-octanoyl-L-homoserine lactone + H2O
-
 Oryctolagus cuniculus N-octanoyl-L-homoserine
-
 ?

Synonyms

Synonyms Comment Organism
AHL-lactonase
-
 Mus musculus
AHL-lactonase
-
 Homo sapiens
AHL-lactonase
-
 Bos taurus
AHL-lactonase
-
 Oryctolagus cuniculus
AHL-lactonase
-
 Capra hircus
AHL-lactonase
-
 Equus caballus
AiiA
-
 Mus musculus
AiiA
-
 Homo sapiens
AiiA
-
 Bos taurus
AiiA
-
 Oryctolagus cuniculus
AiiA
-
 Capra hircus
AiiA
-
 Equus caballus
lactonase-like enzyme
-
 Mus musculus
lactonase-like enzyme
-
 Homo sapiens
lactonase-like enzyme
-
 Bos taurus
lactonase-like enzyme
-
 Oryctolagus cuniculus
lactonase-like enzyme
-
 Capra hircus
lactonase-like enzyme
-
 Equus caballus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens
37
-
 assay at Bos taurus
37
-
 assay at Oryctolagus cuniculus
37
-
 assay at Capra hircus
37
-
 assay at Equus caballus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
95
-
 inactivation within 3 min Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Bos taurus
7.4
-
 assay at Oryctolagus cuniculus
7.4
-
 assay at Capra hircus
7.4
-
 assay at Equus caballus