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Literature summary for 3.1.1.8 extracted from
- Comparison of atypical and usual human serum cholinesterase (1978), J. Biol. Chem., 253, 361-366.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00008 | - |
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide | usual enzyme | Homo sapiens |  |
| 0.002 | - |
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide | atypical enzyme | Homo sapiens | |
| 0.005 | - |
Benzoylcholine | usual enzyme | Homo sapiens | |
| 0.024 | - |
Benzoylcholine | atypical enzyme | Homo sapiens | |
| 0.14 | - |
o-nitrophenylbutyrate | usual and atypical enzyme | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | atypical and usual enzymes differ only in the structure of their anionic site | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| atypical and typical enzyme | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 97 | - |
benzoylcholine | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzoylcholine + H2O | atypical and usual enzyme | Homo sapiens | benzoate + choline | - |
? | |
| benzoylcholine + H2O | benzoylcholine chloride | Homo sapiens | benzoate + choline | - |
? | |
| additional information | atypical and usual enzymes differ only in the structure of their anionic site | Homo sapiens | ? | - |
? | |
| N-methyl-(7-dimethylcarbamoxy)quinolinium iodide + H2O | atypical and usual enzyme | Homo sapiens | ? | - |
? | |
| o-nitrophenylbutyrate + H2O | atypical and usual enzyme | Homo sapiens | o-nitrophenol + butanoate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | four active sites per tetramer in atypical and usual enzyme | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000417 | - |
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide | usual and atypical enzyme | Homo sapiens | |
| 250 | - |
Benzoylcholine | usual and atypical enzyme | Homo sapiens | |
| 800 | - |
o-nitrophenylbutyrate | usual and atypical enzyme | Homo sapiens | |
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