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Literature summary for 3.1.1.8 extracted from
- Quantification of butyrylcholinesterase activity as a sensitive and specific biomarker of Alzheimers disease (2017), J. Alzheimers Dis., 58, 491-505 .
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | butyrylcholinesterase activity is a sensitive and specific biomarker of Alzheimers disease (AD), BChE-associated amyloid-beta plaques has the potential as an improved AD biomarker. The predictive value of BChE as a biomarker for AD facilitates timely disease diagnosis and management | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylcholine + H2O | Homo sapiens | - |
choline + butyrate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | from postmortem brain tissues with Alzheimer's disease, amyloid-beta plaques, cognitively normal without plaques, and other common dementias including corticobasal degeneration, frontotemporal dementia with tau, dementia with Lewy bodies, and vascular dementia. Orbitofrontal cortex, entorhinal cortex, amygdala, and hippocampal formation. Amyloid-beta and BChE-associated pathologies are greater in Alzheimer's disease, particularly in the orbitofrontal cortex. In Alzheimer's disease, the neocortex is one of the earliest areas for accumulation of amyloid-beta pathology | Homo sapiens | - |
| additional information | no association of BChE to pathology in other neurodegenerative disorders, cases from corticobasal degeneration (CBD), one frontotemporal dementia with tau (FTD-tau), one dementia with Lewy bodies (DLB), and one vascular dementia (VaD) are examined | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylcholine + H2O | - |
Homo sapiens | choline + butyrate | - |
? | |
| butyrylthiocholine + H2O | histochemic activity detection | Homo sapiens | thiocholine + butyrate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Homo sapiens |
| butyrylcholinesterase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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