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Literature summary for 3.1.1.8 extracted from

  • Larik, F.A.; Shah, M.S.; Saeed, A.; Shah, H.S.; Channar, P.A.; Bolte, M.; Iqbal, J.
    New cholinesterase inhibitors for Alzheimers disease structure activity relationship, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives (2018), Int. J. Biol. Macromol., 116, 144-150 .
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
1-butanoyl-3-(2,6-dimethylphenyl) thiourea
-
 Homo sapiens
1-butanoyl-3-(3-methoxyphenyl)thiourea
-
 Homo sapiens
1-butanoyl-3-(4-chlorophenyl)thiourea
-
 Homo sapiens
1-butanoyl-3-benzylthiourea
-
 Homo sapiens
galantamine
-
 Homo sapiens
additional information structure-activity relationships, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives, overview Homo sapiens
N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
-
 Homo sapiens
N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(2-methoxyphenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(3-nitrophenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(4-methoxyphenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(4-methylphenyl)carbamothioyl]butanamide
-
 Homo sapiens
N-[(4-nitrophenyl)carbamothioyl]butanamide
-
 Homo sapiens
neostigmine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
butyrylcholine + H2O Homo sapiens
-
 choline + butyrate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P06276
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylcholine + H2O
-
 Homo sapiens choline + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
BuChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00696
-
 pH 7.7, 37°C Homo sapiens 1-butanoyl-3-(3-methoxyphenyl)thiourea
0.0155
-
 pH 7.7, 37°C Homo sapiens N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
0.0162
-
 pH 7.7, 37°C Homo sapiens 1-butanoyl-3-(4-chlorophenyl)thiourea
0.0231
-
 pH 7.7, 37°C Homo sapiens N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
0.0365
-
 pH 7.7, 37°C Homo sapiens N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
0.0366
-
 pH 7.7, 37°C Homo sapiens N-[(4-methylphenyl)carbamothioyl]butanamide
0.0439
-
 pH 7.7, 37°C Homo sapiens N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
0.0496
-
 pH 7.7, 37°C Homo sapiens neostigmine
0.0645
-
 pH 7.7, 37°C Homo sapiens N-[(3-nitrophenyl)carbamothioyl]butanamide
0.0681
-
 pH 7.7, 37°C Homo sapiens N-[(4-nitrophenyl)carbamothioyl]butanamide
0.0741
-
 pH 7.7, 37°C Homo sapiens N-[(4-methoxyphenyl)carbamothioyl]butanamide
0.0758
-
 pH 7.7, 37°C Homo sapiens N-[(2-methoxyphenyl)carbamothioyl]butanamide
0.113
-
 pH 7.7, 37°C Homo sapiens 1-butanoyl-3-benzylthiourea
0.121
-
 pH 7.7, 37°C Homo sapiens 1-butanoyl-3-(2,6-dimethylphenyl) thiourea
0.15
-
 pH 7.7, 37°C Homo sapiens N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
6.6
-
 pH 8.0, 25°C Homo sapiens galantamine