Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | - |
Equus caballus | |
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | - |
Equus caballus | |
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | - |
Equus caballus | |
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | - |
Equus caballus | |
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | - |
Equus caballus | |
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | - |
Equus caballus | |
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | - |
Equus caballus | |
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | - |
Equus caballus | |
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | neuroprotective effect of K3-2 against H2O2-induced toxicity | Equus caballus | |
2-(4-hydroxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | - |
Equus caballus | |
2-(4-hydroxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | - |
Equus caballus | |
2-(4-hydroxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | - |
Equus caballus | |
3-oxo-N-[(1,2,3,4-tetrahydroacridin-9-ylamino)methyl]butanamide | - |
Equus caballus | |
3-oxo-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]butanamide | - |
Equus caballus | |
3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | - |
Equus caballus | |
3-oxo-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]butanamide | - |
Equus caballus | |
additional information | design, synthesis, and biological evaluation of multifunctional tacrine-curcumin hybrids as cholinesterase inhibitors with metal ions-chelating and neuroprotective properties, overview. The hybrid compounds show good cholinesterase inhibitory activity, some of the compounds exhibit different selectivity on acetylcholinesterase (EC 3.1.1.7) or butyrylcholinesterase due to the structural difference. Structure-activity relationships, molecular modelling, overview | Equus caballus | |
tacrine | - |
Equus caballus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Equus caballus | P81908 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Equus caballus | - |
serum | - |
Equus caballus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
butyrylthiocholine + H2O | - |
Equus caballus | thiocholine + butyrate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BChE | - |
Equus caballus |
butyrylcholinesterase | - |
Equus caballus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Equus caballus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Equus caballus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH 8.0, 37°C | Equus caballus | tacrine | |
0.00006 | - |
pH 8.0, 37°C | Equus caballus | 3-oxo-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]butanamide | |
0.00016 | - |
pH 8.0, 37°C | Equus caballus | 3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | |
0.0002 | - |
pH 8.0, 37°C | Equus caballus | 2-(4-hydroxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | |
0.00022 | - |
pH 8.0, 37°C | Equus caballus | 2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | |
0.00022 | - |
pH 8.0, 37°C | Equus caballus | 3-oxo-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]butanamide | |
0.00031 | - |
pH 8.0, 37°C | Equus caballus | 3-oxo-N-[(1,2,3,4-tetrahydroacridin-9-ylamino)methyl]butanamide | |
0.00039 | - |
pH 8.0, 37°C | Equus caballus | 2-(4-hydroxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | |
0.00083 | - |
pH 8.0, 37°C | Equus caballus | 2-(4-hydroxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | |
0.00131 | - |
pH 8.0, 37°C | Equus caballus | 2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | |
0.0015 | - |
pH 8.0, 37°C | Equus caballus | (2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | |
0.0016 | - |
pH 8.0, 37°C | Equus caballus | (2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | |
0.00187 | - |
pH 8.0, 37°C | Equus caballus | (2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide | |
0.00211 | - |
pH 8.0, 37°C | Equus caballus | (2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | |
0.00224 | - |
pH 8.0, 37°C | Equus caballus | (2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide | |
0.00338 | - |
pH 8.0, 37°C | Equus caballus | 2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide | |
0.00477 | - |
pH 8.0, 37°C | Equus caballus | (2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme homology modeling, molecular modeling, overview | Equus caballus |