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Literature summary for 3.1.1.8 extracted from

  • Hagstrom, D.; Hirokawa, H.; Zhang, L.; Radic, Z.; Taylor, P.; Collins, E.S.
    Planarian cholinesterase in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation (2017), Arch. Toxicol., 91, 2837-2847 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
BW284c51 reversible inhibitor Dugesia japonica
Carbaryl low inhibition, irreversible inhibitor Dugesia japonica
chlorpyrifos oxon irreversible inhibitor Dugesia japonica
diazinon oxon high inhibition, irreversible inhibitor Dugesia japonica
dichlorvos irreversible inhibitor Dugesia japonica
donepezil reversible inhibitor Dugesia japonica
edrophonium reversible inhibitor Dugesia japonica
ethopropazine reversible inhibitor Dugesia japonica
malaoxon low inhibition, irreversible inhibitor Dugesia japonica
additional information the quaternary pyridinium aldoximes, pralidoxime (2-PAM) and a lead zwitterionic oxime (RS194B), are both able to reactivate DjChE ATCh hydrolyzing activity at concentrations of 4 mM. Also NaF can reactivate DjChE activity, and the rate of reactivation shows a linear dependence on fluoride concentration. Reactivation of DjChE is significantly more rapid with 10 mM NaF than with 4 mM 2-PAM Dugesia japonica
neostigmine high inhibition, irreversible inhibitor Dugesia japonica
paraoxon irreversible inhibitor Dugesia japonica
physostigmine irreversible inhibitor Dugesia japonica
propidium reversible inhibitor Dugesia japonica
pyridostigmine irreversible inhibitor Dugesia japonica
tacrine reversible inhibitor Dugesia japonica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
butyrylcholine + H2O Dugesia japonica
-
choline + butyrate
-
?

Organism

Organism UniProt Comment Textmining
Dugesia japonica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylcholine + H2O
-
Dugesia japonica choline + butyrate
-
?

Synonyms

Synonyms Comment Organism
BTCh
-
Dugesia japonica
cholinesterase
-
Dugesia japonica
DjChE
-
Dugesia japonica
Djche1
-
Dugesia japonica
Djche2
-
Dugesia japonica
More cf. EC 3.1.1.7 Dugesia japonica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Dugesia japonica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Dugesia japonica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Dugesia japonica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.023
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate butyrylcholine Dugesia japonica BW284c51
0.089
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate butyrylcholine Dugesia japonica BW284c51
0.091
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate butyrylcholine Dugesia japonica ethopropazine
0.22
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate butyrylcholine Dugesia japonica ethopropazine

General Information

General Information Comment Organism
evolution as one of the most ancient true cholinesterases, DjChE provides insight into the evolution of a hybrid enzyme before the separation into distinct AChE and BChE enzymes found in higher vertebrates Dugesia japonica
physiological function the majority of Dugesia japonica cholinesterase (DjChE) activity departs from conventional AChE and BChE classifications Dugesia japonica