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Literature summary for 3.1.1.8 extracted from

  • Yang, W.; Xue, L.; Fang, L.; Chen, X.; Zhan, C.
    Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine (2010), Chem. Biol. Interact., 187, 148-152.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0083
-
butyrylthiocholine mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
0.021
-
butyrylthiocholine wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
0.029
-
acetylthiocholine wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
0.037
-
acetylthiocholine mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Homo sapiens thiocholine + acetate
-
?
butyrylthiocholine + H2O best enzyme for the wild type enzyme Homo sapiens thiocholine + butyrate
-
?

Synonyms

Synonyms Comment Organism
BChE
-
Homo sapiens
butyrylcholinesterase
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
46.67
-
butyrylthiocholine mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
160.2
-
acetylthiocholine mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
336.7
-
acetylthiocholine wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
491.7
-
butyrylthiocholine wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4333
-
acetylthiocholine mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
11500
-
acetylthiocholine wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
23330
-
butyrylthiocholine mutant enzyme A199S/S287G/A328W/Y332G, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens
56670
-
butyrylthiocholine wild type enzyme, at 25°C, in 0.1 M potassium phosphate, pH 7.5 Homo sapiens