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Literature summary for 3.1.1.8 extracted from

  • Nachon, F.; Carletti, E.; Wandhammer, M.; Nicolet, Y.; Schopfer, L.; Masson, P.; Lockridge, O.
    X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger (2011), Biochem. J., 434, 73-82.
    View publication on PubMed
Search for more literature for 3.1.1.8

Cloned(Commentary)

Cloned (Comment) Organism
mutant GG117H is expressed in CHO cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant enzyme G117H without additives and bound to MgF3-, sulfate, echothiophate, or VX, hanging drop vapor diffusion method Homo sapiens

Protein Variants

Protein Variants Comment Organism
G117H the mutation leads to the creation of organophosphylate hydrolase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P06276
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
echothiophate + H2O substrate for mutant enzyme G117H Homo sapiens ?
-
 ?
ethyl ([2-[bis(propan-2-yl)amino]ethyl]-sulfanyl)(methyl)phosphinate + H2O substrate for mutant enzyme G117H Homo sapiens ?
-
 ?
sarin + H2O substrate for mutant enzyme G117H Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens