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Literature summary for 3.1.1.8 extracted from

  • Musilek, K.; Komloova, M.; Zavadova, V.; Holas, O.; Hrabinova, M.; Pohanka, M.; Dohnal, V.; Nachon, F.; Dolezal, M.; Kuca, K.; Jung, Y.S.
    Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications (2010), Bioorg. Med. Chem. Lett., 20, 1763-1766.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
1,1'-(2E)-but-2-ene-1,4-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-(2Z)-but-2-ene-1,4-diyldipyridinium dichloride
-
 Homo sapiens
1,1'-(benzene-1,2-diyldimethanediyl)dipyridinium dibromide
-
 Homo sapiens
1,1'-(benzene-1,3-diyldimethanediyl)dipyridinium dibromide
-
 Homo sapiens
1,1'-(benzene-1,4-diyldimethanediyl)dipyridinium dibromide
-
 Homo sapiens
1,1'-(naphthalene-2,7-diyldimethanediyl)dipyridinium dibromide
-
 Homo sapiens
1,1'-(oxydiethane-2,1-diyl)dipyridinium dibromide
-
 Homo sapiens
1,1'-(oxydimethanediyl)dipyridinium dichloride
-
 Homo sapiens
1,1'-butane-1,4-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-decane-1,10-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-heptane-1,7-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-hexane-1,6-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-nonane-1,9-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-octane-1,8-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-pentane-1,5-diyldipyridinium dibromide
-
 Homo sapiens
1,1'-undecane-1,11-diyldipyridinium dibromide
-
 Homo sapiens
neostigmine
-
 Homo sapiens
pyridostigmine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
BChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
-
 Homo sapiens neostigmine
0.0008
-
-
 Homo sapiens 1,1'-(naphthalene-2,7-diyldimethanediyl)dipyridinium dibromide
0.005
-
-
 Homo sapiens 1,1'-decane-1,10-diyldipyridinium dibromide
0.006
-
-
 Homo sapiens 1,1'-nonane-1,9-diyldipyridinium dibromide
0.007
-
-
 Homo sapiens 1,1'-undecane-1,11-diyldipyridinium dibromide
0.029
-
-
 Homo sapiens 1,1'-octane-1,8-diyldipyridinium dibromide
0.078
-
-
 Homo sapiens 1,1'-heptane-1,7-diyldipyridinium dibromide
0.12
-
-
 Homo sapiens 1,1'-pentane-1,5-diyldipyridinium dibromide
0.13
-
-
 Homo sapiens 1,1'-hexane-1,6-diyldipyridinium dibromide
0.345
-
-
 Homo sapiens 1,1'-(benzene-1,2-diyldimethanediyl)dipyridinium dibromide
0.529
-
-
 Homo sapiens 1,1'-(benzene-1,4-diyldimethanediyl)dipyridinium dibromide
0.541
-
-
 Homo sapiens 1,1'-(2E)-but-2-ene-1,4-diyldipyridinium dibromide
0.583
-
-
 Homo sapiens 1,1'-(oxydimethanediyl)dipyridinium dichloride
1.27
-
-
 Homo sapiens 1,1'-(2Z)-but-2-ene-1,4-diyldipyridinium dichloride
1.38
-
-
 Homo sapiens 1,1'-(benzene-1,3-diyldimethanediyl)dipyridinium dibromide
2.36
-
-
 Homo sapiens 1,1'-(oxydiethane-2,1-diyl)dipyridinium dibromide
9.8
-
-
 Homo sapiens 1,1'-butane-1,4-diyldipyridinium dibromide
16
-
-
 Homo sapiens pyridostigmine