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Literature summary for 3.1.1.8 extracted from
- Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population (2008), Pharmacogenet. Genomics, 18, 213-218.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene BCHE located at chromosome 3q26.1-q26.2, DNA and amino acid sequence determination and analysis, genotyping in Brasilian population and polymorpshisms, expression of mutants in HEK-293T cells and CHO cells, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A184V | naturally occuring mutation in exon 2 | Homo sapiens |
| A539T | naturally occuring mutation in exon 4 | Homo sapiens |
| D70G | naturally occuring mutation in exon 2 | Homo sapiens |
| E255D | naturally occuring mutation in exon 2 | Homo sapiens |
| G115D | naturally occuring mutation in exon 2 | Homo sapiens |
| G333C | naturally occuring mutation, the mutant shows about 80% decreases enzyme activity compared to the wild-type enzyme | Homo sapiens |
| G390V | naturally occuring mutation in exon 2 | Homo sapiens |
| K12R | naturally occuring mutation in exon 2 | Homo sapiens |
| additional information | genotyping in Southern Brasilian population and polymorpshisms of the BCHE alleles, overview | Homo sapiens |
| R470W | naturally occuring mutation in exon 2 | Homo sapiens |
| T234M | naturally occuring mutation in exon 2 | Homo sapiens |
| V294M | naturally occuring mutation in exon 2 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0118 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant V294M | Homo sapiens |  |
| 0.0169 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant R470W | Homo sapiens | |
| 0.0273 | - |
butyrylthiocholine | pH 7.0, 25°C, wild-type enzyme | Homo sapiens | |
| 0.0316 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant K12R | Homo sapiens | |
| 0.0357 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant G333C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
Brasilian population, gene BCHE | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylthiocholine + H2O | detection by 5,5-dithiobis(2-nitrobenzoic acid) | Homo sapiens | butyrate + thiocholine | - |
? | |
| propionylthiocholine + H2O | detection by 5,5-dithiobis(2-nitrobenzoic acid) | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Homo sapiens |
| butyrylcholinesterase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 98 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant G333C | Homo sapiens | |
| 338 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant V294M | Homo sapiens | |
| 490 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant R470W | Homo sapiens | |
| 500 | - |
butyrylthiocholine | pH 7.0, 25°C, wild-type enzyme | Homo sapiens | |
| 585 | - |
butyrylthiocholine | pH 7.0, 25°C, mutant K12R | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
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