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Literature summary for 3.1.1.8 extracted from
- Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria (2008), J. Enzyme Inhib. Med. Chem., 23, 313-316.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-[cyano(3-indolyl)methylene]-3-indolone | an alkaloid isolated from Isatis tinctoria | Equus caballus |  |
| 3'-hydroxyepiglucoisatisin | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
| baicalein | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
| epiglucoisatisin | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
| galanthamine | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
| isatan A | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
| isatan B | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
| sulfoglucobrassicin | an alkaloid isolated from Isatis tinctoria | Equus caballus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylthiocholine + H2O | detection by 5,5-dithiobis(2-nitrobenzoic acid) | Equus caballus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Equus caballus |
| butyrylcholinesterase | - |
Equus caballus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Equus caballus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Equus caballus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0085 | - |
pH 8.0, 25°C | Equus caballus | galanthamine | |
| 0.0163 | - |
pH 8.0, 25°C | Equus caballus | 3'-hydroxyepiglucoisatisin | |
| 0.0197 | - |
pH 8.0, 25°C | Equus caballus | epiglucoisatisin | |
| 0.0235 | - |
pH 8.0, 25°C | Equus caballus | 2-[cyano(3-indolyl)methylene]-3-indolone | |
| 0.0248 | - |
pH 8.0, 25°C | Equus caballus | sulfoglucobrassicin | |
| 0.0434 | - |
pH 8.0, 25°C | Equus caballus | isatan A | |
| 0.0476 | - |
pH 8.0, 25°C | Equus caballus | isatan B | |
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