Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a a quadruple mutant cocaine hydrolase CocH with improved catalytic efficiency for cocaine, the mutant enzyme is expressed as albumin fusion protein and introduced in rats, male and female Wistar rats, showing enzyme activity but also high enzyme decay rates | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | Homo sapiens | - |
acetate + thiocholine | - |
? | |
butyrylthiocholine + H2O | Homo sapiens | - |
butyrate + thiocholine | - |
? | |
cocaine + H2O | Homo sapiens | - |
ecgonine methyl ester + benzoate | - |
? | |
additional information | Homo sapiens | butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Homo sapiens | acetate + thiocholine | - |
? | |
butyrylthiocholine + H2O | - |
Homo sapiens | butyrate + thiocholine | - |
? | |
cocaine + H2O | - |
Homo sapiens | ecgonine methyl ester + benzoate | - |
? | |
additional information | butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | BChE tetrameric forms are much longer-lived than monomers | Homo sapiens |
tetramer | BChE tetrameric forms are much longer-lived than monomers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
BChE | - |
Homo sapiens |
butyrylcholinesterase | - |
Homo sapiens |