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Literature summary for 3.1.1.8 extracted from

  • Piazzi, L.; Belluti, F.; Bisi, A.; Gobbi, S.; Rizzo, S.; Bartolini, M.; Andrisano, V.; Recanatini, M.; Rampa, A.
    Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones (2007), Bioorg. Med. Chem., 15, 575-585.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate
-
 Homo sapiens
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
 Homo sapiens
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
 Homo sapiens
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
 Homo sapiens
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
 Homo sapiens
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
 Homo sapiens
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
 Homo sapiens
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
 Homo sapiens
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
 Homo sapiens
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
 Homo sapiens
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
 Homo sapiens
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
 Homo sapiens
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
 Homo sapiens
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
 Homo sapiens
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
 Homo sapiens
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
 Homo sapiens
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
 Homo sapiens
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones structure-activity relationships, overview, inhibition with high selectivity toward BuChE Homo sapiens
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
 Homo sapiens
xanthostigmine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O
-
 Homo sapiens thiocholine + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
BuChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
-
 Homo sapiens 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
0.0001
-
-
 Homo sapiens 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
0.0001
-
-
 Homo sapiens 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
0.00012
-
-
 Homo sapiens 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
0.00015
-
-
 Homo sapiens 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
0.00032
-
-
 Homo sapiens 3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
0.0008
-
-
 Homo sapiens 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
0.00093
-
-
 Homo sapiens 3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
0.001
-
-
 Homo sapiens 3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
0.00127
-
-
 Homo sapiens 3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
0.00143
-
-
 Homo sapiens 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
0.00185
-
-
 Homo sapiens 3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
0.00191
-
-
 Homo sapiens 3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
0.00201
-
-
 Homo sapiens 3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
0.00211
-
-
 Homo sapiens 3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
0.00249
-
-
 Homo sapiens 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
0.00265
-
-
 Homo sapiens 3-[4-(benzylmethylamino)butoxy]xanthen-9-one
0.00308
-
-
 Homo sapiens 6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
0.00833
-
-
 Homo sapiens 3-[3-(benzylmethylamino)propoxy]xanthen-9-one
0.014
-
-
 Homo sapiens 3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
0.0165
-
-
 Homo sapiens 3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate
0.0295
-
-
 Homo sapiens 3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
0.0461
-
-
 Homo sapiens 3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
0.048
-
-
 Homo sapiens xanthostigmine
0.0638
-
-
 Homo sapiens 3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
0.127
-
-
 Homo sapiens 3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
0.269
-
-
 Homo sapiens 3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one