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Literature summary for 3.1.1.8 extracted from

  • Primozic, I.; Hrenar, T.; Tomic, S.; Meic, Z.
    Stereoselective hydrolysis of quaternary quinuclidinium benzoates catalyzed by butyrylcholinesterase (2003), Eur. J. Org. Chem., 2003, 295-301.
No PubMed abstract available
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide inhibition at 0.01 mM and 0.02 mM Equus caballus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.023
-
 (R)-3-benzoyloxy-1-benzylquinuclidinium bromide 24°C Equus caballus
0.065
-
 (S)-3-benzoyloxy-1-methylquinuclidinium iodide 24°C Equus caballus
0.127
-
 (R)-3-benzoyloxy-1-methylquinuclidinium iodide 24°C Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
-
 Equus caballus ?
-
 ?
(R)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
-
 Equus caballus ?
-
 ?
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
-
 Equus caballus ?
-
 ?
(S)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
-
 Equus caballus ?
-
 ?
butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?
additional information enzyme favors the R-enantiomer Equus caballus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.2
-
 (S)-3-benzoyloxy-1-methylquinuclidinium iodide 24°C Equus caballus
97
-
 (R)-3-benzoyloxy-1-benzylquinuclidinium bromide 24°C Equus caballus
227
-
 (R)-3-benzoyloxy-1-methylquinuclidinium iodide 24°C Equus caballus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0033
-
 (S)-3-benzoyloxy-1-benzylquinuclidinium bromide 24°C Equus caballus